Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 52, Pages 27011-27017Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1905658116
Keywords
spinal GRPR(+) neurons; inhibitory control; galanin(+) GABAergic neurons; rostral ventromedial medulla; gating itch processing
Categories
Funding
- National Natural Science Foundation of China [31825013]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX05]
- Program of Shanghai Academic/Technology Research Leader [19XD1424200]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB32010200]
Ask authors/readers for more resources
Spinal gastrin-releasing peptide receptor-expressing (GRPR(+)) neurons play an essential role in itch signal processing. However, the circuit mechanisms underlying the modulation of spinal GRPR(+) neurons by direct local and long-range inhibitory inputs remain elusive. Using viral tracing and electrophysiological approaches, we dissected the neural circuits underlying the inhibitory control of spinal GRPR(+) neurons. We found that spinal galanin GABAergic neurons form inhibitory synapses with GRPR(+) neurons in the spinal cord and play an important role in gating the GRPR(+) neuron-dependent itch signaling pathway. Spinal GRPR(+) neurons also receive inhibitory inputs from local neurons expressing neuronal nitric oxide synthase (nNOS). Moreover, spinal GRPR(+) neurons are gated by strong inhibitory inputs from the rostral ventromedial medulla. Thus, both local and long-range inhibitory inputs could play important roles in gating itch processing in the spinal cord by directly modulating the activity of spinal GRPR(+) neurons.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available