Journal
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
Volume 95, Issue 10, Pages 590-601Publisher
JAPAN ACAD
DOI: 10.2183/pjab.95.040
Keywords
molecular machines; molecular triggers and switches; molecular recognition; homotropic allosterism; aggregation-induced emission; aggregation-based chirality segregation
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The need to measure the concentration of selected ions and small organic molecules in both in vivo and in vitro processes is continuously increasing beyond the borders of various research fields. This need has been fulfilled using host-guest chemistry, or in general, by the use of molecular recognition. The basic idea in these research fields was derived from the 1 : 1 host-guest interaction based on the key-and-lock concept. However, we have experienced that only with this classical concept, more precise, higher-order recognition faces serious difficulty. In this review article, I wish to explain that the introduction of two new concepts, i.e., the dynamic action of molecular systems and the amplification effect of molecular assemblies, overcame the limitation of the key-and-lock concept. In fact, we have found that even complete chirality segregation can be achieved under optimal conditions.
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