Journal
POLYCYCLIC AROMATIC COMPOUNDS
Volume 42, Issue 1, Pages 277-289Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10406638.2020.1726976
Keywords
5-Aminopyrazole; copper (II) triflate; isatin; multicomponent synthesis; spirooxindole
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Funding
- Public Projects of Zhejiang Province of China [LGG19B020002]
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This study presents a simple and efficient method for the synthesis of spirooxindole derivatives. The method involves a three-component reaction of isatin, 5-aminopyrazole, and 1,3-dicarbonyl compounds (or beta-oxo-benzenepropanenitrile), catalyzed by copper triflate in ethanol. The advantages of this method are high efficiency, mild reaction conditions, recoverable catalyst, and environmentally friendly conditions.
A simple and efficient method for the synthesis of spirooxindole derivatives via a three-component reaction of isatin, 5-aminopyrazole, and 1,3-dicarbonylcompounds (or beta- oxo-benzenepropanenitril e) catalyzed by copper triflate in ethanol is described. The advantages of this method include high efficiency, mild reaction conditions, recoverable catalyst, and environmentally benign conditions.
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