Synthesis of Trisubstituted 1,3-Thiazoles Using Gly-Pro-Glu (Tripeptide) Supported on Superparamagnetic Silica-Encapsulated γ-Fe2O3 Nanoparticles through Efficient Multi-Component Reaction in Water

Gly-Pro-Glu tripeptide supported on superparamagnetic silica-encapsulated gamma-Fe2O3 nanoparticles -used as a magnetically recyclable heterogeneous catalyst- was synthesized. The catalyst was characterized by powder X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive spectrum (EDS), thermo-gravimetric analysis (TGA), vibrating sample magnetometry (VSM), and Fourier transform infrared spectroscopy (FT-IR). MNPs-Gly-Pro-Glu was applied for the efficient synthesis of trisubstituted 1,3-thiazole derivatives. The catalyst demonstrated a superior catalytic activity toward the green one-pot synthesis of trisubstituted 1,3-thiazole via three-component reactions between arylglyoxals, cyclic-1,3-dicarbonyls and thiobenzamides in water. More importantly, the synthesized catalyst was separated easily by using an external magnet and was reused for ten runs without intense loss of catalytic activity. [GRAPHICS] Gly-Pro-Glu tripeptide supported on superparamagnetic silica-encapsulated gamma-Fe2O3 nanoparticles was synthesized. MNPs-Gly-Pro-Glu was applied for the efficient synthesis of trisubstituted 1,3-thiazole derivatives. The catalyst demonstrated a superior catalytic activity toward the green one-pot synthesis of trisubstituted 1,3-thiazole via three-component reactions between arylglyoxals, cyclic-1,3-dicarbonyls and thiobenzamides in water.

Automated summary

The study synthesized Gly-Pro-Glu tripeptide supported on superparamagnetic silica-encapsulated gamma-Fe2O3 nanoparticles as a magnetically recyclable catalyst for efficient synthesis of 1,3-thiazole derivatives. The catalyst showed superior catalytic activity and could be reused for ten cycles without losing activity.