Journal
PHYTOCHEMISTRY LETTERS
Volume 35, Issue -, Pages 211-215Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2019.12.008
Keywords
Herbal medicine; Natural product; 2-arylbenzofuran; Sesbagrandiflorain; Sesbania grandiflora
Categories
Funding
- Directorate of Research and Community Services, The Ministry of Research, Technology and Higher Education, Republic of Indonesia [393/UN26.21/PN/2018, 123.44/D2.3/KP/2018]
- Oregon State University NMR Facility - National Institutes of Health, HEI Grant [1S10OD018518]
- M. J. Murdock Charitable Trust grant [2014162]
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A new 2-arylbenzofuran, sesbagrandiflorain C (1), together with four known compounds, 2-(3,4-dihydroxy-2-methoxyphenyl)-4-hydroxy-6-methoxybenzofuran-3-carbaldehyde (2), 2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxybenzofuran-3-carboxaldehyde (3), sesbagrandiflorain A (4) and sesbagrandiflorain B (5), have been isolated from the stem bark of an Indonesian plant, Sesbania grandiflora (L.) Pers. The chemical structure of compound 1 was elucidated by UV, IR, MS, and NMR spectroscopic techniques. The proton and carbon NMR resonances of 1 were also compared with the predicted chemical shifts obtained from DFT quantum mechanical calculations with Gaussian. None of the compounds showed antibacterial activity against Bacillus subtilis, Escherichia coli, Mycobacterium smegmatis, Pseudomonas aeruginosa, and Staphylococcus aureus in an agar diffusion assay. However, sesbagrandiflorains A (4) and B (5) exhibited moderate activity against Mycobacterium tuberculosis H37Rv. In addition, compounds 1 - 5 have moderate cytotoxicity against HeLa, HepG2, and MCF-7 cancer cell lines.
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