Journal
PHYTOCHEMISTRY LETTERS
Volume 35, Issue -, Pages 63-67Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2019.11.002
Keywords
Chisocheton pentandrus; Pentandricine B-D; Cytotoxic activity; MCF-7 breast cancer lines; Limonoid
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Funding
- Directorate General of Scientific Resources, Technology and Higher Education, Ministry of Research, Technology and Higher Education, Indonesia (World Class Professor Grant) [T/83/D2.3/KK.04.05/2019]
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Three new limonoids namely pentandricines B-D (1-3), were isolated from n-hexane extract of the stem bark of Chisocheton pentandrus, along with four known limonoids (4-7). The chemical structures of pentandricines B-D, were fully elucidated based on UV, IR, HR-TOFMS, 1D- and 2D-NMR spectra. Furthermore, compounds 1-7 were evaluated for their cytotoxic activity against MCF-7 breast cancer cells in vitro, with compound 7 (nimonol) showing strongest cytotoxicity activity with an IC50, value of 22.03 +/- 0.026 mu M.
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