The effect of the smoking on choroidal thickness, central macular vascular and optic disc perfusion

Objectives: To compare choroidal thickness, central macular vascular perfusion and optic disc perfusion in smokers and non-smokers. Methods: Smoker participants defined group I and non-smoker participants(group II) Optical coherence tomography angiography (OCTA) performed to all volunteers and choroidal thickness, central macular vascular and optic disc perfusion were measured. Results: In group I, 30 eyes of the 30 participants (6 male and 24 female) evaluated and in group II, 32 eyes of the 32 participants (13 male and 19 female) evaluated. The mean age of the volunteers were 43.09 +/- 14.28 and 42.2 +/- 8.24 year-old in group I and group II, respectively. The mean choroidal thickness were 345 +/- 74 mu m and 301.6 +/- 71 mu m in group I and group II, respectively (p = 0.022). The mean optic disc perfusions were 45.17 +/- 1.46% and 45.25 +/- 1.43% in group I and group II, respectively (p = 0.82). The mean central macular vascular perfusions were 20.20 +/- 7.17% and 18.65 +/- 7.46% in group I and group II, respectively (p = 0.4). There are a negative correlation between macular vascular perfusion, optic disc perfusion and smoking period (p = 0.32 and 0.62, respectively.) Conclusion: Our study revealed that smoking statistically significantly effected choroidal thickness but effected central macular vascular and optic disc perfusion changes were not statistically significant.