Journal
PHARMACOLOGICAL RESEARCH
Volume 151, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2019.104541
Keywords
Oxymatrine; Inflammation; Cancer; Apoptosis; Fibrosis; Nociception
Categories
Funding
- National Key R&D Program of China [2017YFC1700301]
- Fundamental Research Funds for the Central public welfare research institutes [ZZ13-024-4]
- Qihuang Scholar of Millions of Talents Project (Qihuang Project) of Traditional Chinese Medicine Inheritance and Innovation
- Beijing NOVA Program [Z171100001117027]
- Special Project for Outstanding Young Talents of China Academy of Chinese Medical Sciences [ZZ13-YQ-001]
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Oxymatrine is a quinazine alkaloid extracted from Sophora flavescens with various therapeutic effects such as organ- and tissue-protective, anti-inflammatory, anti-cancer, and anti-viral effects. In this review, we summarize the protective effects of oxymatrine on damaged organs and tissues by analyzing both in vivo and in vitro studies. The mechanisms of protective effects of oxymatrine are mainly related to its anti-inflammatory, anti-oxidative stress, anti- or pro-apoptotic, anti-fibrotic, metabolism-regulation, and anti-nociceptive functions. In addition, a variety of signal pathways, cells, and molecules are influenced by oxymatrine, and by these comprehensive actions, maximum therapeutic effects can be achieved. Furthermore, we summarize the protective effects in clinical studies and adverse effects of oxymatrine. It is believed that through more in-depth animal experiments and standardized clinical research, oxymatrine holds a bright future in the process of organ and tissue protection and has a significant therapeutic promise to translate from bench to bedside.
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