Journal
PHARMACEUTICAL RESEARCH
Volume 37, Issue 3, Pages -Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-020-2763-8
Keywords
histidine; photostability; protein oxidation; radicals; reaction mechanisms; tryptophan; tyrosine
Funding
- Genentech
- Genentech Foundation
- Amgen
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Purpose: Therapeutic proteins are sensitive to photo-degradation by UV A and visible light. As none of the essential amino acids exhibits significant absorption in the UV A and visible light regions, the underlying mechanisms of photo-degradation induced by UV A and visible light are not well understood. This review addresses potential mechanisms, by which protein structure, oxidative modifications or impurities can promote the photo-degradation of therapeutic proteins during the exposure to UV A and visible light.
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