Related references
Note: Only part of the references are listed.Impact of Precipitation of Antibody Therapeutics After Subcutaneous Injection on Pharmacokinetics and Immunogenicity
Francis Kinderman et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2019)
Proteins and antibodies in serum, plasma, and whole blood-size characterization using asymmetrical flow field-flow fractionation (AF4)
Mats Leeman et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2018)
Hydrogels in three-dimensional dendritic cell (MUTZ-3) culture as a scaffold to mimic human immuno competent subcutaneous tissue
Floriane Groell et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)
In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Hanne Kinnunen Bown et al.
JOURNAL OF CONTROLLED RELEASE (2018)
Challenges and Opportunities for the Subcutaneous Delivery of Therapeutic Proteins
Michael R. Turner et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2018)
Multiplex Matrix Metalloproteinases Analysis in the Cerebrospinal Fluid Reveals Potential Specific Patterns in Multiple Sclerosis Patients
Massimiliano Castellazzi et al.
FRONTIERS IN NEUROLOGY (2018)
Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions
Ingrid Schmid et al.
COMMUNICATIONS BIOLOGY (2018)
Prediction of intraocular antibody drug stability using ex-vivo ocular model
Sulabh Patel et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)
Sustained release ophthalmic dexamethasone: In vitro in vivo correlations derived from the PK-Eye
Sahar Awwad et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)
Determination of isoelectric points and relative charge variants of 23 therapeutic monoclonal antibodies
Alexandre Goyon et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2017)
Perspectives on Subcutaneous Route of Administration as an Immunogenicity Risk Factor for Therapeutic Proteins
Lora Hamuro et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
If Euhydric and Isotonic Do Not Work, What Are Acceptable pH and Osmolality for Parenteral Drug Dosage Forms?
Dieter Roethlisberger et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance
Bjorn Boll et al.
MOLECULAR PHARMACEUTICS (2017)
Pharmacokinetic aspects of retinal drug delivery
Eva M. del Amo et al.
PROGRESS IN RETINAL AND EYE RESEARCH (2017)
Rheological behaviour of vitreous humour
Andreia F. Silva et al.
RHEOLOGICA ACTA (2017)
Immunoaffinity capture coupled with capillary electrophoresis - mass spectrometry to study therapeutic protein stability in vivo
Mei Han et al.
ANALYTICAL BIOCHEMISTRY (2017)
Assessment of disulfide and hinge modifications in monoclonal antibodies
Bernd Moritz et al.
ELECTROPHORESIS (2017)
A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins
Katherine L. Gill et al.
AAPS JOURNAL (2016)
Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion
Christian Dragatin et al.
EXPERIMENTAL DERMATOLOGY (2016)
Characterization of the pH and Temperature in the Rabbit, Pig, and Monkey Eye: Key Parameters for the Development of Long-Acting Delivery Ocular Strategies
Florence Lorget et al.
MOLECULAR PHARMACEUTICS (2016)
Biochemical analysis of the living human vitreous
Jan Kokavec et al.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2016)
Intrathecal Trastuzumab Halts Progression of CNS Metastases in Breast Cancer
Guilhem Bousquet et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
Physical and Chemical Stability of Antibody Drug Conjugates: Current Status
Philip L. Ross et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2016)
Subcutaneous Injection Volume of Biopharmaceuticals-Pushing the Boundaries
Roman Mathaes et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2016)
Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters
William R. Strohl
BIODRUGS (2015)
Evaluation of protein drug stability with vitreous humor in a novel ex-vivo intraocular model
Sulabh Patel et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)
A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components
Hanne M. Kinnunen et al.
JOURNAL OF CONTROLLED RELEASE (2015)
The PK-Eye: A Novel In Vitro Ocular Flow Model for Use in Preclinical Drug Development
Sahar Awwad et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Dextrose-mediated aggregation of therapeutic monoclonal antibodies in human plasma: Implication of isoelectric precipitation of complement proteins
Shen Luo et al.
MABS (2015)
Basic concepts about brain pathophysiology and intracranial pressure monitoring
G. Rodriguez-Boto et al.
NEUROLOGIA (2015)
Intraventricular cerebrospinal fluid temperature analysis using MR diffusion-weighted imaging thermometry in Parkinson's disease patients, multiple system atrophy patients, and healthy subjects
Kaoru Sumida et al.
BRAIN AND BEHAVIOR (2015)
Vitreous humor thermodynamics during phacoemulsification
Guillermo Salcedo-Villanueva et al.
INTERNATIONAL OPHTHALMOLOGY (2015)
Therapeutic monoclonal antibodies and consistent ends: terminal heterogeneity, detection, and impact on quality
Kurt Brorson et al.
CURRENT OPINION IN BIOTECHNOLOGY (2014)
Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site
Hanne M. Kinnunen et al.
JOURNAL OF CONTROLLED RELEASE (2014)
In vitro and in vivo modifications of recombinant and human IgG antibodies
Hongcheng Liu et al.
MABS (2014)
A new look at cerebrospinal fluid circulation
Thomas Brinker et al.
FLUIDS AND BARRIERS OF THE CNS (2014)
IgG1 Thioether Bond Formation in Vivo
Qingchun Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
The Antibody Drug Absorption Following Subcutaneous or Intramuscular Administration and Its Mathematical Description by Coupling Physiologically Based Absorption Process with the Conventional Compartment Pharmacokinetic Model
Liang Zhao et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2013)
Aggregation of biopharmaceuticals in human plasma and human serum Implications for drug research and development
Tudor Arvinte et al.
MABS (2013)
Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies
Sheng Yin et al.
PHARMACEUTICAL RESEARCH (2013)
In-depth mass spectrometric mapping of the human vitreous proteome
Sebastian Aretz et al.
PROTEOME SCIENCE (2013)
Rates and impact of human antibody glycation in vivo
Andrew M. Goetze et al.
GLYCOBIOLOGY (2012)
Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release
Wim Jiskoot et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration
Yanan Zheng et al.
MABS (2012)
Visualization of subcutaneous insulin injections by x-ray computed tomography
M. Thomsen et al.
PHYSICS IN MEDICINE AND BIOLOGY (2012)
INTERSTITIAL FLUID AND LYMPH FORMATION AND TRANSPORT: PHYSIOLOGICAL REGULATION AND ROLES IN INFLAMMATION AND CANCER
Helge Wiig et al.
PHYSIOLOGICAL REVIEWS (2012)
Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum
Vasco Filipe et al.
PHARMACEUTICAL RESEARCH (2012)
Lymphatic Transport and Catabolism of Therapeutic Proteins after Subcutaneous Administration to Rats and Dogs
Weirong Wang et al.
DRUG METABOLISM AND DISPOSITION (2012)
C-Terminal Lysine Processing of Human Immunoglobulin G2 Heavy Chain In Vivo
Bing Cai et al.
BIOTECHNOLOGY AND BIOENGINEERING (2011)
Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies
Weirong Wang et al.
MOLECULAR IMMUNOLOGY (2011)
Fragmentation of monoclonal antibodies
Josef Vlasak et al.
MABS (2011)
Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations
Vasco Filipe et al.
PHARMACEUTICAL RESEARCH (2011)
Electrostatic interactions of monoclonal antibodies with subcutaneous tissue
Henryk Mach et al.
THERAPEUTIC DELIVERY (2011)
Studies in serum support rapid formation of disulfide bond between unpaired cysteine residues in the VH domain of an immunoglobulin G1 molecule
D. Ouellette et al.
ANALYTICAL BIOCHEMISTRY (2010)
Characterization of trisulfide modification in antibodies
Sheng Gu et al.
ANALYTICAL BIOCHEMISTRY (2010)
Physico-chemical studies of molecular interactions between non-ionic surfactants and bovine serum albumin
Miriam Ruiz-Pena et al.
COLLOIDS AND SURFACES B-BIOINTERFACES (2010)
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
Natalia Wegner et al.
IMMUNOLOGICAL REVIEWS (2010)
Assessing monoclonal antibody product quality attribute criticality through clinical studies
Andrew M. Goetze et al.
MABS (2010)
Stability of IgG isotypes in serum
Ivan R. Correia
MABS (2010)
Stability of Protein Pharmaceuticals: An Update
Mark Cornell Manning et al.
PHARMACEUTICAL RESEARCH (2010)
A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: A study by analytical ultracentrifugation
Barthelemy Demeule et al.
ANALYTICAL BIOCHEMISTRY (2009)
Human antibody Fc deamidation in vivo
Y. Diana Liu et al.
BIOLOGICALS (2009)
The effect of Fc glycan forms on human IgG2 antibody clearance in humans
Xiaoyu Chen et al.
GLYCOBIOLOGY (2009)
Physiology of vitreous surgery
Einar Stefansson
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2009)
Measurement of PO2 during vitrectomy for central retinal vein occlusion, a pilot study
Tom H. Williamson et al.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2009)
Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality
John F. Carpenter et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2009)
Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo
Aran F. Labrijn et al.
NATURE BIOTECHNOLOGY (2009)
A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior
Cynthia Quan et al.
ANALYTICAL BIOCHEMISTRY (2008)
Glycation during storage and administration of monoclonal antibody formulations
Stefan Fischer et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2008)
Adult vitreous structure and postnatal changes
M. M. Le Goff et al.
EYE (2008)
Human IgG2 antibodies display disulfide-mediated structural isoforms
Jette Wypych et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass
Thomas M. Dillon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Human IgG2 Antibody Disulfide Rearrangement in Vivo
Y. Diana Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Behaviour of polysorbate 20 during dialysis, concentration and filtration using membrane separation techniques
Hanns-Christian Mahler et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2008)
Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
Conrad E. Johanson et al.
FLUIDS AND BARRIERS OF THE CNS (2008)
The function, composition and analysis of cerebrospinal fluid in companion animals: Part I - Function and composition
Roberta Di Terlizzi et al.
VETERINARY JOURNAL (2006)
A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles
Sai T. Reddy et al.
JOURNAL OF APPLIED PHYSIOLOGY (2006)
Strategies to improve plasma half life time of peptide and protein drugs
M. Werle et al.
AMINO ACIDS (2006)
Characterization of immunoglobulin G fragments in liquid intravenous immunoglobulin products
RV Diemel et al.
TRANSFUSION (2005)
Evaluation of coupled convective-diffusive transport of drugs administered by intravitreal injection and controlled release implant
J Park et al.
JOURNAL OF CONTROLLED RELEASE (2005)
Measurement of cerebrospinal fluid oxygen partial pressure in humans using MRI
G Zaharchuk et al.
MAGNETIC RESONANCE IN MEDICINE (2005)
In vivo deamidation characterization of monoclonal antibody by LC/MS/MS
LH Huang et al.
ANALYTICAL CHEMISTRY (2005)
Lymphatic transport of proteins after s.c. injection: implications of animal model selection
CJH Porter et al.
ADVANCED DRUG DELIVERY REVIEWS (2001)
Role of formulation vehicles in taxane pharmacology
L van Zuylen et al.
INVESTIGATIONAL NEW DRUGS (2001)
Molecular clocks
NE Robinson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Structural macromolecules and supramolecular organisation of the vitreous gel
PN Bishop
PROGRESS IN RETINAL AND EYE RESEARCH (2000)
Share Paper
