Journal
PERSONALIZED MEDICINE
Volume 17, Issue 2, Pages 155-170Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/pme-2019-0110
Keywords
Africa; communicable diseases; genetic variation; noncommunicable diseases; pharmacogenetics; pharmacogenomics; precision medicine
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Funding
- National Human Genome Research Institute of the National Institutes of Health [U24HG006941]
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Effective interventions and treatments for complex diseases have been implemented globally, however, coverage in Africa has been comparatively lower due to lack of capacity, clinical applicability and knowledge on the genetic contribution to disease and treatment. Currently, there is a scarcity of genetic data on African populations, which have enormous genetic diversity. Pharmacogenomics studies have the potential to revolutionise treatment of diseases, therefore, African populations are likely to benefit from these approaches to identify likely responders, reduce adverse side effects and optimise drug dosing. This review discusses clinical pharmacogenetics studies conducted in African populations, focusing on studies that examined drug response in complex diseases relevant to healthcare. Several pharmacogenetics associations have emerged from African studies, as have gaps in knowledge.
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