Journal
PEDIATRIC DIABETES
Volume 22, Issue 1, Pages 40-46Publisher
WILEY
DOI: 10.1111/pedi.12979
Keywords
diabetic ketoacidosis; SEARCH for Diabetes in Youth registry; type 1 diabetes; type 2 diabetes; YDR registry
Categories
Funding
- Wake Forest University School of Medicine [200-2010-35171, U01 DP000250, U48/CCU919219, U18DP006131]
- Seattle Children's Hospital [U18DP002710-01, U01 DP000244, U58/CCU019235-4, U18DP006136]
- University of North Carolina at Chapel Hill [U18DP002708, U01 DP000254, U48/CCU419249, U18DP006138]
- Cincinnati's Children's Hospital Medical Center [1U18DP002709, U01 DP000248, U48/CCU519239, U18DP006134]
- University of Colorado Denver [U18DP000247-06A1, U01 DP000247, U48/CCU819241-3, U18DP006139]
- Kaiser Permanente Southern California [U48/CCU919219, U18DP002714, U01 DP000246, U18DP006133]
- Centers for Disease Control and Prevention [U18DP006136, U18DP006138, U18DP006134, U18DP006139, U18DP006133, 1U18DP006131, DP-10-001, DP-05-069, 00097]
- National Institute of Diabetes and Digestive and Kidney Diseases
- Ohio Department of Health
- University of Cincinnati, NIH/NCATS [UL1 TR001425, UL1 TR000077]
- University of Colorado at Denver [P30 DK57516]
- University of Colorado Pediatric Clinical and Translational Research Center, NIH/NCATS [UL1 TR000154]
- Seattle Children's Hospital
- University of Washington, NIH/NCATS [UL1 TR00423]
- Medical University of South Carolina, NIH/National Center for Advancing Translational Sciences (NCATS) [UL1 Tr001450, UL1 TR000062]
- Southern California Permanente Medical Group
- Kaiser Foundation Health Plan
- Indian Council of Medical Research
- National Institutes of Health [R21DK105869-02]
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A comparison study was conducted on the prevalence of DKA at diagnosis among youth with type 1 and type 2 diabetes in the United States and India. The results showed a significantly higher DKA prevalence in youth with T1D in the US compared to India, especially among younger age groups. The prevalence of DKA among T2D patients did not differ significantly between the two countries.
Background There is significant global variation in the prevalence of diabetic ketoacidosis (DKA) at diagnosis among youth with type 1 diabetes (T1D). However, data for youth with type 2 diabetes (T2D) are limited, even in developed countries. We compared the prevalence of DKA at diagnosis among individuals with T1D and T2D from the SEARCH for Diabetes in Youth (SEARCH) and the Registry of Youth Onset Diabetes in India (YDR) registries. Methods We harmonized the SEARCH and YDR registries to the structure and terminology in the Observational Medical Outcome Partnership Common Data Model. Data used were from youth with T1D and T2D diagnosed before 20 years and newly diagnosed between 2006 and 2012 in YDR and 2009 and 2012 in SEARCH. Results There were 5366 US youth (4078 with T1D, 1288 with T2D) and 2335 Indian youth (2108 with T1D, 227 with T2D). More than one third of T1D youth enrolled in SEARCH had DKA at diagnosis which was significantly higher than in YDR (35.3% vs 28.7%, P < .0001). The burden of DKA in youth with T1D was significantly higher among younger age groups; this relationship was similar across registries (P = .4). The prevalence of DKA among T2D in SEARCH and YDR were 5.5% and 6.6% respectively (P = .4). Conclusions There is significant burden of DKA at diagnosis with T1D among youth from United States and India, especially among the younger age groups. The reasons for this high prevalence are largely unknown but are critical to developing interventions to prevent DKA at diagnosis.
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