Journal
PANCREATOLOGY
Volume 20, Issue 3, Pages 409-418Publisher
ELSEVIER
DOI: 10.1016/j.pan.2020.01.003
Keywords
Pancreatic stellate cells; Pancreatic cancer; Stromal-tumour interactions; Desmoplastic reaction; Tumour microenvironment
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Funding
- National Health and Medical Research Council of Australia
- Cancer Council of New South Wales, Australia
- Cancer Institute, NSW
- Hirshberg Foundation
- Avner Pancreatic Cancer Foundation, Australia
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Tumour-stromal interactions have now been acknowledged to play a major role in pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a specific cell type in the pancreas-the pancreatic stellate cell (PSC). Pancreatic stellate cells (PSCs) are a unique resident cell type of pancreas and with a critical role in both healthy and diseased pancreas. Accumulating evidence indicates that PSCs interact closely with cancer cells as well as with other cell types of the stroma such as immune cells, endothelial cells and neuronal cells, to set up a growth permissive microenvironment for pancreatic tumours, which facilitates local tumour growth as well as distant metastasis. Consequently, recent work in the field has focused on the development of novel therapeutic approaches targeting the stroma to inhibit PC progression. Such a multi-pronged approach targeting both tumour and stromal elements of PC has been successfully applied in pre-clinical settings. The challenge now is to translate the pre-clinical findings into the clinical setting to achieve better outcomes for pancreatic cancer patients. (C) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.
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