Journal
BIOSENSORS & BIOELECTRONICS
Volume 63, Issue -, Pages 472-477Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.07.083
Keywords
Plasmonics; Nanorod array; Localized surface plasmon resonance; Biosensing; Discrete dipole approximation; Single nucleotide polymorphism
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Funding
- Singapore National Research Foundation [NRF-RF2009-06]
- Nanyang Technological University [M58110061]
- Singapore Ministry - Education via two Tier 2 [MOE2011-T2-2-051, MOE2011-T2-2-085]
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Engineering plasmonic nanomaterials or nanostructures towards ultrasensitive biosensing for disease markers or pathogens is of high importance. Here we demonstrate a systematic approach to tailor effective plasmonic nanorod arrays by combining both comprehensive numerical discrete dipole approximations (DDA) simulation and transmission spectroscopy experiments. The results indicate that 200 x 50 nm nanorod arrays with 300 x 500 nm period provide the highest figure of merit (FOM) of 2.4 and a sensitivity of 310 nm/RIU. Furthermore, we demonstrate the use of nanorod arrays for the detection of single nucleotide polymorphism in codon 12 of the K-ras gene that are frequently occurring in early stages of colon cancer, with a sensitivity down to 10 nM in the presence of 100-fold higher concentration of the homozygous genotypes. Our work shows significant potential of nanorod arrays towards point-of-care applications in diagnosis and clinical studies. (C) 2014 Elsevier B.V. All rights reserved.
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