Journal
ORGANIC LETTERS
Volume 22, Issue 4, Pages 1458-1463Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00028
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Funding
- SERB, New Delhi [EMR/2016/001161]
- CSIR, New Delhi
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The first feedback inhibition, similar to enzyme catalysis, in the Co(III)salen-catalyzed asymmetric ring-opening reaction of N-free spiro-epoxyoxyindole has been discovered, which leads dynamic kinetic to kinetic resolution. This is the first report of the enantioselective construction of all carbon quaternary center from any epoxide employing metal-salen catalyst until date. This protocol provides an easy access of 3-(3- indolyl)oxindole methanols, a privileged building block for the synthesis of a large variety of 3,3'-bisindole alkaloids.
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