Journal
ORGANIC LETTERS
Volume 22, Issue 4, Pages 1448-1452Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00042
Keywords
-
Categories
Funding
- National Science Foundation [CHE-1565788]
- National Institutes of Health [AI146485, AI144196, AI142040, CA213201]
Ask authors/readers for more resources
An asymmetric synthesis of two analogues of SL0101 (1) has been achieved. The effort is aimed at the discovery of inhibitors of the p90 ribosomal S6 kinase (RSK) with improved bioavailability. The route relies upon the use of the Taylor catalyst to regioselectively install C-3 '' acetyl or carbamate functionality. This study led to the identification of a third-generation analogue of SL0101 with a C-4 '' n-Pr-carbamate and a C-3 '' acetate with improved RSK inhibitory activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available