Journal
ORGANIC LETTERS
Volume 22, Issue 3, Pages 1193-1198Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00072
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Funding
- NSFC [21801191, 21572163, 21873074]
- Wenzhou Science & Technology Bureau [G20180016]
- College Students Innovation and Entrepreneurship Training Program [JWSC2018079]
- Laboratory open project of Wenzhou University [JW19SK65]
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An efficient cobalt-catalyzed Z to E isomerization of beta-substituted styrenes using the amido-diphosphine ligand was developed, delivering the (E)-isomers with good functional tolerance and high stereoselectivity. The reaction could be scaled up to gram-scale with a catalyst loading of 0.1 mol %, using a mixture of (Z)- and (E)-alkene as the starting material. Preliminary mechanistic studies indicated that cobalt(I)-hydride and a benzylic-cobalt species were probably involved in the reaction, as supported by experiments and DFT calculations.
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