Journal
ORGANIC LETTERS
Volume 22, Issue 3, Pages 908-913Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04452
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Funding
- National Natural Science Foundation of China [21871147, 91956106, 21602114]
- Fundamental Research Funds for Central Universities
- Tencent Foundation via the Xplorer Prize
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ortho-Selective carbene C-H insertion of unprotected phenols is achieved with dimethyl diazomalonate under the catalysis of [Rh(COD)Cl](2). After the C-H insertion, subsequent cyclization and electrophilic addition of another carbene molecule affords tris-carboxylate-substituted 2-benzofuranones as the final reaction products. The enantioselective variant has been developed with the use of chiral diene ligands. Mechanistic experiments indicate that a transient oxonium ylide directing group might be responsible for the regiocontrol at the C-H activation step.
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