Journal
ORGANIC LETTERS
Volume 22, Issue 3, Pages 818-822Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04253
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Funding
- National Natural Science Foundation of China [21532003, 21871152, 21790332]
- 111 Project [B06005]
- Ministry of Education of China
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A highly efficient asymmetric hydrogenation of gamma- and delta-ketoacids was developed by using a chiral Spiro iridium catalyst (S)-1a, affording the optically active gamma- and delta-hydroxy acids/lactones in high yields with excellent enantioselectivities (up to >99% ee) and turnover numbers (TON up to 100000). This protocol provides an efficient and practical method for enantioselective synthesis of Ezetimibe.
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