Journal
ORGANIC LETTERS
Volume 22, Issue 3, Pages 1155-1159Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00005
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Funding
- Shenzhen Overseas High-level Talents Innovation Plan of Technical Innovation Project [KQJSCX20180319114439973]
- Research Grants Council of Hong Kong [HKUST 16304416]
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A highly efficient asymmetric synthesis of chiral thiochromanones is developed via Cu(I)/phosphoramidite catalyzed asymmetric alkynylation of thiochromones under mild reaction conditions. The catalyst system is tolerant of various thiochromone precursors and terminal alkynes. The established asymmetric transformation provides different enatiomeric-enriched thiochromanones with more molecular complexity and enables access to chiral thioflavanones, a subgroup of flavonoid by further functionalization.
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