4.8 Article

Photo/N-Heterocyclic Carbene Co-catalyzed Ring Opening and γ-Alkylation of Cyclopropane Enal

Journal

ORGANIC LETTERS
Volume 22, Issue 3, Pages 986-990

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04533

Keywords

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Funding

  1. National Natural Science Foundation of China [21425207, 21672216, 21831008]
  2. Beijing National Laboratory for Molecular Sciences [BNLMS-CXXM-202003]

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An unprecedented photo/NHC-co-catalyzed ring-opening C-C bond cleavage of cyclopropane enal and the following gamma-alkylation with a halogenated compound via radicals were established, affording the corresponding gamma-alkylated alpha,beta-unsaturated esters in moderate to good yields.

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