Journal
ORGANIC LETTERS
Volume 22, Issue 3, Pages 929-933Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04484
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Funding
- National Natural Science Foundation of China [21532007, 21772213]
- Drug Innovation Major Project of China [2018ZX09711001-001-005]
- Biological Resources Program, CAS of China [KFJBRP-008]
- Shanghai Rising-Star Program Foundation (SCST) [19QA1410800]
- Youth Innovation Promotion Association CAS
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Crokonoid A (1), a highly rearranged diterpenoid featuring a dual-bridged tricyclo[4.4.1.1(1,4)]dodecane-2,11-dione ring system and its two possible ent-kaurene diterpenoid precursors (2 and 3), was isolated and structurally characterized by solid data from Croton kongensis. Compound 1 exhibited significant cytotoxicity against HL-60 and A-549 cell lines with IC50 values of 1.24 +/- 0.56 and 1.92 +/- 0.60 mu M, respectively.
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