Journal
ORGANIC LETTERS
Volume 22, Issue 3, Pages 884-890Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04432
Keywords
-
Categories
Funding
- University of Toledo
Ask authors/readers for more resources
An aerobic catalytic oxidation process is described for the olefin oxyamination using acids and primary amines as the sources of O and N. Our mechanistic findings point to the formation of triiodide as a critical catalytic intermediate to account for the tolerance of electron-rich nucleophiles. This dual iodide and copper catalytic system is suitable for a formal [5+1] annulation process to access valuable lactam structures and highlighted by the synthesis of the pharmaceutical Zamifenacin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available