Journal
ORGANIC LETTERS
Volume 22, Issue 6, Pages 2135-2140Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00081
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- Univ. of Toledo
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The utilization of a halogen bond in a number of chemical fields is well-known. Surprisingly, the incorporation of this useful noncovalent interaction in chemical reaction engineering is rare. We disclose here an uncommon use of halogen bonding to induce intermolecular C-sp(3)-H amination while enabling a hydrogen atom transfer relay strategy to access privileged pyrrolidine structures directly from alkanes. Mechanistic studies support the presence of multiple halogen bond interactions at distinct reaction stages.
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