Journal
ORGANIC LETTERS
Volume 22, Issue 2, Pages 438-442Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04191
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Funding
- NSFC [21525208, 21801066]
- Henan Educational Committee [19A150028, 20B350001]
- Henan Normal University [qd16111, 2019QK04]
- Natural Science Foundation of Henan Province [182300410131]
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Rh(III)-catalyzed coupling between acrylic acids and yndienones has been realized for the synthesis of cis-hydrobenzofuranone. The reaction proceeded in excellent regio- and stereoselectivity under mild and redox-neutral conditions via a sequence of carboxylic acid-directed olefinic C-H activation, alkyne insertion, and Michael addition. Representative products were found to exhibit cytotoxicity toward the A549 cancer cell line at micromolar levels.
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