Journal
ORGANIC LETTERS
Volume 22, Issue 2, Pages 357-360Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03751
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Funding
- National Natural Science Foundation of China [21602001, 21922109, 21672196, 21831007]
- Fundamental Research Funds for the Central Universities of China [WK2060190086]
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A CuSO4-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO4 serves as a low-cost ligand-free redox catalyst. This reaction provides a practical modular synthesis of N-aryl indoles from isonitriles.
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