Journal
ORGANIC LETTERS
Volume 22, Issue 1, Pages 331-334Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04400
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- RWTH Aachen University
- JARA-HPC from RWTH Aachen University [jara0091]
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We herein disclose the use of tetramethylammonium fluoride (TMAF) as a direct and selective methylating agent of a variety of amides, indoles, pyrroles, imidazoles, alcohols, and thiols. The method is characterized by operational simplicity, wide scope, and ease of purification. Our computational studies suggest a concerted methylation-deprotonation as the preferred reaction pathway.
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