Journal
ORGANIC LETTERS
Volume 22, Issue 1, Pages 145-149Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04064
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The growing interest in marine natural substances as potential new drugs has made total synthesis a real asset for structure confirmation. Trichormamide C (1), a cyclic lipopeptide isolated from the cyanobacteria Oscillatoria sp., is characterized by the presence of nonproteinogenic amino acids in the sequence. Trichormamide C structural confirmation was carried out through the implementation of a flexible synthesis resulting in two new analogs (3 and 4).
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