Journal
ORGANIC LETTERS
Volume 21, Issue 24, Pages 10063-10068Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04010
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Funding
- Chung-Ang University
- National Research Foundation of Korea (NRF) - Korean Government (MSICT) [NRF-2015R1A5A1008958, NRF-2019R1A2C2089953]
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The synthesis of isoxazoles has been achieved in a continuous flow system composed of two reaction units: the Friedel Crafts acylation of alkynes and the azide conjugate addition to the resulting beta-chlorovinyl ketones followed by a photochemical thermal reaction sequence. The salient feature of the current flow system includes the safe handling of potentially explosive organic azide species as well as the rapid conversion of batch reactions into flow conditions with the integration of multiple reactor units.
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