Journal
ORGANIC LETTERS
Volume 21, Issue 24, Pages 10043-10047Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03982
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A new lysine-reactive cyclopropropyl aldehyde for the covalent modification of proteins was developed. The reagent exploits a divinylcyclopropane-cycloheptadiene rearrangement to render the initial condensation irreversible. A labeling study on eGFP demonstrated excellent chemoselectivity for the modification of amine-nucleophiles with the possibility of subsequent modifications.
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