Journal
ONCOLOGY REPORTS
Volume 43, Issue 3, Pages 986-998Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2020.7463
Keywords
abdominal adhesion; probiotics; high-throughput sequencing; TGF-beta 1; Smad signalling pathway; fibrosis
Categories
Funding
- National Natural Science Foundation of China [81960103, 31560264]
- Natural Science Foundation of Jiangxi province [20192ACBL20034]
- Excellent Youth Foundation of the Jiangxi Scientific Committee [20171BCB23028]
- Science and Technology Plan of the Jiangxi Health Planning Committee [20175526]
- Science and Technology Project of Jiangxi [20181BBG70028, 20181BCB24003]
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Abdominal adhesions refer to abnormal adhesions which cause a series of complications in numerous patients. In the present study, the beneficial effect of a combination of probiotics (Lactobacillus plantarum, L. acidophilus, L. rhamnosus and Bifidobacterium animalis) on abdominal adhesions in a rat model were verified. The present results indicated that probiotic treatment significantly reduced the levels of proinflammatory factors interleukin (IL)-1 beta, IL-6 and TNF-alpha in serum and intestinal tissue (P<0.05), and markedly downregulated the inflammatory (TLR4/NF-kappa B) and fibrotic (TGF-beta 1/Smad) signalling pathways in intestinal tissue, especially in the prevention group (P<0.01). The high-throughput sequencing results further supported that the probiotics significantly increased the relative abundance of probiotic Bacteroidetes (at the phylum level), Bacteroidales (at the order level), Lactobacillales (at the order level) and Lactobacillus (at the genus level), and markedly reduced the number of pathogenic Proteobacteria (at the phylum level), Erysipelotrichales (at the order level), Verrucomicrobiales (at the order level), Klebsiella (at the genus level) and Serratia (at the genus level). In conclusion, probiotics can effectively reduce abdominal adhesions by restoring the microbial balance and reducing inflammation and fibrosis caused by surgery.
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