Long-term Outcome of Zonal Outer Retinopathy in Punctate Inner Choroidopathy or Multifocal Choroiditis

Purpose: To report the long-term prognosis of punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC) and associated zonal outer retinopathy (ZOR). Method: Retrospective study in patients with PIC/MFC and ZOR with a clinical follow-up of 4 years or longer. Results: There were 14 patients in this study (M: F = 11:3). All patients received systemic steroid therapy. The initial and final median logarithm of minimal angle of resolution of BCVA were 1.00 and 0.22 (p = .002). Ellipsoid zone recovery was noted in all patients. The median visual field loss improved from -6.38 dB to -3.41 dB (p = .035). The median of total area of PIC/MFC lesions enlarged from 6.82 mm(2) to 8.77 mm(2) (p = .005). Recurrent disease was noted in 4 eyes and maintenance steroid was needed in 3 eyes. Conclusion: With steroid therapy, most patients with PIC/MFC and ZOR had good visual prognosis.

Automated summary

Most patients with PIC/MFC and ZOR had good visual prognosis with systemic steroid therapy, showing improvement in ellipsoid zone and visual field loss. However, some patients may experience disease recurrence despite receiving maintenance steroid therapy.