4.3 Article

Reproducibility of Full-field Electroretinogram Measurements in Birdshot Chorioretinopathy Patients: An Intra- and Inter-visit Analysis

Journal

OCULAR IMMUNOLOGY AND INFLAMMATION
Volume 29, Issue 5, Pages 848-853

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/09273948.2019.1697824

Keywords

Electroretinography; birdshot chorioretinopathy; test variability

Categories

Funding

  1. National Eye Institute Intramural Research Program, National Institutes of Health

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The study investigated the variability of ffERG measurements in stable birdshot chorioretinopathy patients, finding that intra-visit variability was lower than inter-visit variability. It was suggested that a 40% reduction in ERG amplitude and/or a delay of >2 msec in the photopic single flash response may be suitable criteria for determining meaningful change in BCR patients.
Purpose: Aims to determine the variability of ffERG measurements in patients with clinically stable birdshot chorioretinopathy (BCR). Methods: Repeatability coefficients (RC) of ffERG amplitudes and implicit times were calculated from 11 BCR patients. Jackknife resampling estimated 95% confidence intervals of each ERG parameter's RC and the percentage change explained by variability alone was calculated. Results: Intra-visit variability in ffERG parameters was lower than inter-visit. Intravisit RCs demonstrated that for intravisit ERG testing, there was less than 30% variation in ERG amplitude for most parameters. For inter-visit ERG testing, a greater than 40% reduction in ERG amplitude may be clinically meaningful for 6 of 8 ERG parameters. Photopic single flash responses have Conclusions: A 40% reduction in ERG amplitude and/or a delay of >2 msec in the photopic single flash response may be suitable criteria for meaningful change in BCR patients.

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