Journal
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
Volume 77, Issue 2, Pages 84-93Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/oemed-2019-105962
Keywords
-
Categories
Funding
- United States Fire Administration
- National Cancer Institute
- National Institute for Occupational Safety and Health
- NATIONAL CANCER INSTITUTE [ZIACP010120] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Objectives To update the mortality experience of a previously studied cohort of 29 992 US urban career firefighters compared with the US general population and examine exposure-response relationships within the cohort. Methods Vital status was updated through 2016 adding 7 years of follow-up. Cohort mortality compared with the US population was evaluated via life table analyses. Full risk-sets, matched on attained age, race, birthdate and fire department were created and analysed using the Cox proportional hazards regression to examine exposure-response associations between select mortality outcomes and exposure surrogates (exposed-days, fire-runs and fire-hours). Models were adjusted for a potential bias from healthy worker survivor effects by including a categorical variable for employment duration. Results Compared with the US population, mortality from all cancers, mesothelioma, non-H odgkin's lymphoma (NHL) and cancers of the oesophagus, intestine, rectum, lung and kidney were modestly elevated. Positive exposure-response relationships were observed for deaths from lung cancer, leukaemia and chronic obstructive pulmonary disease (COPD). Conclusions This update confirms previous findings of excess mortality from all cancers and several site-specific cancers as well as positive exposure-response relations for lung cancer and leukaemia. New findings include excess NHL mortality compared with the general population and a positive exposure-response relationship for COPD. However, there was no evidence of an association between any quantitative exposure measure and NHL.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available