4.1 Article

The pathway to pyrimidines: The essential focus on dihydroorotate dehydrogenase, the mitochondrial enzyme coupled to the respiratory chain

Related references

Note: Only part of the references are listed.
Article Cell Biology

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Maria Hytti et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Cell Biology

Brain pyrimidine nucleotide synthesis and Alzheimer disease

Alba Pesini et al.

AGING-US (2019)

Article Medicine, Research & Experimental

Antiviral effects of selected IMPDH and DHODH inhibitors against foot and mouth disease virus

Mei-jiao Gong et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Biochemistry & Molecular Biology

The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion

Vilma Dembitz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Review Pharmacology & Pharmacy

Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer

Joseph T. Madak et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Article Multidisciplinary Sciences

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

Yuanyuan Wang et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

New perspectives on the roles of pyrimidines in the central nervous system

M. Loeffler et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2018)

Review Biochemistry & Molecular Biology

The Role of Mitochondrial Dysfunction in the Progression of Alzheimer's Disease

Claus Desler et al.

CURRENT MEDICINAL CHEMISTRY (2018)

Article Clinical Neurology

CAD mutations and uridine-responsive epileptic encephalopathy

Johannes Koch et al.

BRAIN (2017)

Article Biochemistry & Molecular Biology

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

Iosifina P. Foskolou et al.

MOLECULAR CELL (2017)

Article Clinical Neurology

CAD mutations and uridine-responsive epileptic encephalopathy

Johannes Koch et al.

BRAIN (2017)

Review Biochemical Research Methods

Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy

Ayse Okesli et al.

CURRENT OPINION IN BIOTECHNOLOGY (2017)

Review Biochemistry & Molecular Biology

The dihydroorotate dehydrogenases: Past and present

Renata A. G. Reis et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2017)

Review Biochemistry & Molecular Biology

Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases

Ju Gao et al.

ANTIOXIDANTS (2017)

Article Biochemistry & Molecular Biology

Coenzyme Q biosynthesis and its role in the respiratory chain structure

Maria Alcazar-Fabra et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2016)

Article Endocrinology & Metabolism

Elevated plasma dihydroorotate in Miller syndrome: Biochemical, diagnostic and clinical implications, and treatment with uridine

John A. Duley et al.

MOLECULAR GENETICS AND METABOLISM (2016)

Article Multidisciplinary Sciences

Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease

Liang Zhang et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors

Bobby G. Ng et al.

HUMAN MOLECULAR GENETICS (2015)

Review Biochemistry & Molecular Biology

Orotic Acid, More Than Just an Intermediate of Pyrimidine de novo Synthesis

Monika Loeffler et al.

JOURNAL OF GENETICS AND GENOMICS (2015)

Article Biochemistry & Molecular Biology

Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria

Martin Hey-Mogensen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Article Multidisciplinary Sciences

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

Issam Ben-Sahra et al.

SCIENCE (2013)

Article Microbiology

Genorne sequence and analysis of Lactobacillus helveticus

Paola Cremonesi et al.

FRONTIERS IN MICROBIOLOGY (2013)

Article Biochemistry & Molecular Biology

Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii

Miryam Andrea Hortua Triana et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2012)

Article Virology

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

Qing-Yin Wang et al.

JOURNAL OF VIROLOGY (2011)

Article Biochemistry & Molecular Biology

GENE EXPRESSION OF ENZYMES REQUIRED FOR THE DE NOVO SYNTHESIS AND DEGRADATION OF PYRIMIDINES IN RAT PERIPHERAL TISSUES AND BRAIN

Johannes Gerlach et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2011)

Article Genetics & Heredity

Exome sequencing identifies the cause of a mendelian disorder

Sarah B. Ng et al.

NATURE GENETICS (2010)

Biographical-Item Biochemistry & Molecular Biology

Dr. Hermione Anne Simmonds (December 6, 1927-April 2, 2010) In memoriam

David Perrett

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2010)

Article Biochemistry & Molecular Biology

Region-Specific Distribution of Dihydroorotate Dehydrogenase in the Rat Central Nervous System Points to Pyrimidine De Novo Synthesis in Neurons

Ch M. Schaefer et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2010)

Article Biochemistry & Molecular Biology

Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase

AN Boa et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2005)

Review Developmental Biology

Friedrich Miescher and the discovery of DNA

R Dahm

DEVELOPMENTAL BIOLOGY (2005)

Review Biochemistry & Molecular Biology

Pyrimidine pathways in health and disease

M Loffler et al.

TRENDS IN MOLECULAR MEDICINE (2005)

Article Biochemistry & Molecular Biology

Transcriptional repression of human cad gene by hypoxia inducible factor-1 alpha

KF Chen et al.

NUCLEIC ACIDS RESEARCH (2005)

Article Chemistry, Medicinal

Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement

J Leban et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)

Article Biochemistry & Molecular Biology

Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration

N Gattermann et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2004)

Article Biochemistry & Molecular Biology

Two different dihydroorotate dehydrogenases from yeast Saccharomyees kluyveri

E Zameitat et al.

FEBS LETTERS (2004)

Article Biochemistry & Molecular Biology

Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells

M Löffler et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2004)

Review Chemistry, Multidisciplinary

Inhibitors of de novo nucleotide biosynthesis as drugs

RI Christopherson et al.

ACCOUNTS OF CHEMICAL RESEARCH (2002)

Review Cell Biology

Megamitochondria formation - physiology and pathology

T Wakabayashi

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2002)

Article Genetics & Heredity

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency

S Sumi et al.

HUMAN GENETICS (2002)

Article Biochemistry & Molecular Biology

p21Cip1 and p27Kip1 regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest

SL Green et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide

C Beuneu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2000)

Article Biochemistry & Molecular Biology

Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase

J Rawls et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

SP Liu et al.

STRUCTURE WITH FOLDING & DESIGN (2000)