Journal
NMR IN BIOMEDICINE
Volume 34, Issue 5, Pages -Publisher
WILEY
DOI: 10.1002/nbm.4257
Keywords
analysis; MRS; preprocessing; processing; quantification; quantitation; water referencing
Funding
- Canadian Institutes of Health Research [PJT-148751, PJT-165869]
- Fonds de Recherche du Quebec - Sante [FRQ: 0000035275]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2017-03875, RGPIN-2014-06072]
- Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung [320030-175984]
- Institutional Centre Cores for Advanced Neuroimaging award [P30 NS076408]
- National Institute of Biomedical Imaging and Bioengineering [P41 EB015894]
- National Institute of Neurological Disorders and Stroke [R01 NS080816]
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This paper reviews the three main steps in the post-acquisition workflow of a single-voxel MRS experiment, which include preprocessing, analysis, and quantification, providing recommendations for best practices at each step.
Once an MRS dataset has been acquired, several important steps must be taken to obtain the desired metabolite concentration measures. First, the data must be preprocessed to prepare them for analysis. Next, the intensity of the metabolite signal(s) of interest must be estimated. Finally, the measured metabolite signal intensities must be converted into scaled concentration units employing a quantitative reference signal to allow meaningful interpretation. In this paper, we review these three main steps in the post-acquisition workflow of a single-voxel MRS experiment (preprocessing, analysis and quantification) and provide recommendations for best practices at each step.
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