Journal
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Volume 95, Issue -, Pages 12-16Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.niox.2019.12.001
Keywords
Nitric oxide; Persistent pulmonary hypertension of the newborn; Pulmonary arterial hypertension; Neonate; Respiratory failure; Bronchopulmonary dysplasia
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Funding
- NIH [R01HL132941, K08 HL132014-01]
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Inhaled nitric oxide is a powerful therapeutic used in neonatology. Its use is evidenced-based for term and near-term infants with persistent pulmonary hypertension; however, it is frequently used off-label both in term and preterm babies. This article reviews the off-label uses of iNO in infants. Rationale is discussed for a selective application of iNO based on physiologically guided principles, and new research avenues are considered.
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