Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 382, Issue 7, Pages 674-678Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMsb1901642
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Funding
- British Heart Foundation [CH/1996001/9454] Funding Source: Medline
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Nonrandomized observational analyses have been promoted as alternatives to randomized clinical trials. However, randomization ensures balance between groups, whereas nonrandomized studies are often biased by between-group differences. Efforts to reduce the cost and complexity of clinical trials are preferable to relying on observational studies.
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