Journal
NEUROSCIENCE RESEARCH
Volume 152, Issue -, Pages 87-107Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2020.01.002
Keywords
Oscillation; Closed-loop intervention; Transcranial electrical stimulation; Neuromodulation; Epilepsy; Psychiatric disorders; Oscillopathy; Oscillotherapeutics
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Funding
- KAKENHI [18KK0236, 19H03550, 19H05224]
- Uehara Memorial Fund
- Kanae Foundation for the Promotion of Medical Science
- EU-FP7-ERC-2013-Starting grant [337075]
- EU [739593]
- Hungarian Academy of Sciences
- National Research, Development and Innovation Office, Hungary [EFOP-3.6.1-16-2016-00008]
- Ministry of Human Capacities, Hungary [20391-3/2018/FEKUSTRAT]
- Life Science Foundation of Japan
- Grants-in-Aid for Scientific Research [19H05224, 18KK0236, 19H03550] Funding Source: KAKEN
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Oscillatory brain activities support many physiological functions from motor control to cognition. Disruptions of the normal oscillatory brain activities are commonly observed in neurological and psychiatric disorders including epilepsy, Parkinson's disease, Alzheimer's disease, schizophrenia, anxiety/trauma-related disorders, major depressive disorders, and drug addiction. Therefore, these disorders can be considered as common oscillation defects despite having distinct behavioral manifestations and genetic causes. Recent technical advances of neuronal activity recording and analysis have allowed us to study the pathological oscillations of each disorder as a possible biomarker of symptoms. Furthermore, recent advances in brain stimulation technologies enable time- and space-targeted interventions of the pathological oscillations of both neurological disorders and psychiatric disorders as possible targets for regulating their symptoms. (C) 2020 Published by Elsevier B.V.
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