Journal
NEUROSCIENCE LETTERS
Volume 715, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2019.134642
Keywords
Heat shock protein 70; Cerebral ischemic stroke; Traumatic brain injury; Neuroprotection; Pharmacological induction
Categories
Funding
- National Institutes of Health [RO1 NS106441, R03 NS101246]
- Veteran's Merit Award [I01 BX000589]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2016R1D1A1B03933017]
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Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addition to their ability to prevent protein denaturation and aggregation, the HSPs have also been shown to modulate many signaling pathways. Among HSPs, the inducible 70 kDa HSP (HSP70) has especially been shown to improve neurological outcome in experimental models of brain ischemia and injury. HSP70 can modulate various aspects of the programmed cell death pathways and inflammation. This review will focus on potential mechanisms of the neuroprotective effects of HSP70 in stroke and brain trauma models. We also comment on potential ways in which HSP70 could be translated into clinical therapies.
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