Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 110, Issue -, Pages 100-113Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2019.03.018
Keywords
Glucose; BDNF; FGF-1; Memory; Epigenetics; Incretins; Vagus nerve
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Funding
- JSPS Wakate B [16K19007, 13F03094]
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Glucose has many diverse physiological roles such as energy metabolism, appetite control and memory consolidation. We recently reported that memory-related gene expression is epigenetically controlled in murine brain cells and that glucose can regulate gene expression in a cell-specific manner. However, the literature reviews have indicated that glucose can also regulate gut cells to release incretins which might play a role in memory processes directly or indirectly by vagus nerve stimulation. In this review, we discussed the effects of glucose on the gut and brain, aiming to understand more in-depth the role of glucose in memory function. In addition, we also discussed the alteration of glucose-signaling in type-2 diabetes mellitus (T2DM) and a possible link to Alzheimer's disease (AD) pathologies.
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