Journal
BIOSENSORS & BIOELECTRONICS
Volume 66, Issue -, Pages 55-61Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.10.068
Keywords
Heparin; SERS; Au@Ag core-shell nanoparticles; Aggregation/segregation
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Funding
- National Natural Science Foundation of China [41273093, 21175101]
- National Major Scientific Instruments and Device Development Project [2012YQ16000701]
- Foundation of China Geological Survey [12120113015200]
- Fundamental Research Funds for the Central Universities [2042014kf0260]
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A sequential 'on/off dual mode SERS assay platform for heparin with wider detection window and higher reliability is constructed based on electrostatic forces, in which the highly protonated chitosan encapsulated p-Mercaptobenzoic acid coated Au@Ag core-shell nanoparticles undergo sequential aggregation/segregation upon the additive of heparin with a limit of detection of 43.74 ng/mL (5.69 U/mL) and a continuous concentration range of 50-800 ng/mL (6.5-104 U/mL), which are lower in sensitivity and wider in detection window than the most reported assay for heparin. Remarkably, the latter declined window over a range of 350-800 ng/mL in contrast, which has not reported before, is extremely important in reliable and practical assay of heparin. (C) 2014 Elsevier B.V. All rights reserved.
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