Journal
NEURON
Volume 104, Issue 6, Pages 1168-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2019.09.043
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Funding
- Agence Nationale pour la Recherche (ANR SENSEMAKER'')
- Fyssen Foundation
- Human Brain Project [WP 3.5.2]
- DIM Region Ile de France''
- Marie Curie Program [CIG 334581]
- International Human Frontier Science Program Organization [CDA-0064-2015]
- Fondation pour l'Audition (Laboratory grant)
- European Research Council (ERC CoG DEEPEN)
- DIM Cerveau et Pensee
- Ecole des Neurosciences de Paris Ile-de-France (ENP)
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Driving perception by direct activation of neural ensembles in cortex is a necessary step for achieving a causal understanding of the neural code for auditory perception and developing central sensory rehabilitation methods. Here, using optogenetic manipulations during an auditory discrimination task in mice, we show that auditory cortex can be short-circuited by coarser pathways for simple sound identification. Yet when the sensory decision becomes more complex, involving temporal integration of information, auditory cortex activity is required for sound discrimination and targeted activation of specific cortical ensembles changes perceptual decisions, as predicted by our readout of the cortical code. Hence, auditory cortex representations contribute to sound discriminations by refining decisions from parallel routes.
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