Journal
NATURE REVIEWS RHEUMATOLOGY
Volume 16, Issue 3, Pages 129-130Publisher
NATURE RESEARCH
DOI: 10.1038/s41584-020-0369-5
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Funding
- National Institutes of Health (NIH), National Institute on Aging [R01AG049058]
- Department of Veterans Affairs [I01BX004666]
- NIH National Institute of Digestive and Kidney Diseases [R24 DK090964, NIH-R56DK114711, NIH-1UG3OD023248]
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Obesity promotes osteoarthritis (OA) through complex and incompletely understood biomechanical, metabolic and inflammatory factors. New data in mice add to this complexity by showing that eating a high-fat diet increases the risk of OA for two generations of offspring, raising questions about disease mechanisms and future treatment strategies.
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