Journal
NATURE NEUROSCIENCE
Volume 23, Issue 1, Pages 1-2Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41593-019-0563-4
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Funding
- NINDS NIH HHS [R01 NS081746, R01 NS123405] Funding Source: Medline
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A new study shows that the enzyme monoamine oxidase funnels a byproduct of dopamine metabolism, H2O2, directly into the mitochondrial electron transport chain, stimulating ATP production. This alternative energy pathway may protect dopaminergic neurons from the toxicity induced by dopamine metabolism while supporting phasic firing.
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