Journal
NATURE BIOTECHNOLOGY
Volume 38, Issue 3, Pages 293-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41587-019-0359-9
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Funding
- Deutsche Forschungsgemeinschaft (DFG), Germany [NT 3/10-1]
- European Research Council (ERC) under the European Union [694968]
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We develop mid-infrared optoacoustic microscopy (MiROM) for label-free, bond-selective, live-cell metabolic imaging, enabling spatiotemporal monitoring of carbohydrates, lipids and proteins in cells and tissues. Using acoustic detection of optical absorption, MiROM converts mid-infrared sensing into a positive-contrast imaging modality with negligible photodamage and high sensitivity. We use MiROM to observe changes in intrinsic carbohydrate distribution from a diffusive spatial pattern to tight co-localization with lipid droplets during adipogenesis. Mid-infrared optoacoustic microscopy enables label-free, bond-selective imaging in living cells
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