4.4 Article

(+)-7-O-Methylisomiroestrol, a new chromene phytoestrogen from the Pueraria candollei var. mirifica root

Journal

NATURAL PRODUCT RESEARCH
Volume 35, Issue 21, Pages 4110-4114

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1727473

Keywords

Pueraria mirifica; methylisomiroestrol; phytoestrogen; oestrogenic assay

Funding

  1. Thailand Research Fund [IRN 61W0005]
  2. Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand

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(+)-7-O-Methylisomiroestrol (MeI), a novel chromene found in the Pueraria candollei var. mirifica (PM) root, has a higher estrogenic potency compared to isomiroestrol but lower than deoxymiroestrol and miroestrol. MeI serves as a new estrogenic biomarker for the chemical standardization of PM extract for health product development.
(+)-7-O-Methylisomiroestrol (MeI), a novel chromene, was discovered as a phytoestrogen in the Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham (PM) root having been used as an active agent against oestrogen depletion disorders. The identification of PM phytochemicals is crucial for the development of standardised botanical drugs of PM. MeI was purified from the root cortex of PM, and its structure was elucidated using NMR and mass spectrometry. The content of MeI in the root bark of the PM root was 2.1-6.5 x 10(-3)% (w/w). The oestrogenic potency of MeI was stronger than that of isomiroestrol but less than that of deoxymiroestrol and miroestrol. Therefore, MeI is a new oestrogenic biomarker for the effective chemical standardisation of the PM extract for health product development.

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