Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 22, Pages 4740-4745Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1715399
Keywords
Sapindus mukorossi Gaertn; antibacterial fraction; Cutibacterium acnes; chemical profile
Categories
Funding
- National First-class Discipline Program of Food Science and Technology [JUFSTR20180509]
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The study evaluated the antibacterial activities of different extracts of Sapindus mukorossi on Cutibacterium acnes, with the optimized extract showing the highest yield of saponins and best antibacterial activity. Transmission electron microscopy revealed destruction of bacterial cell membrane and wall, leading to cell lysis and death. Oleanane-type triterpenoid saponins were speculated to contribute to the antibacterial activities of the optimized extract.
This study evaluated the antibacterial activities of different extracts of Sapindus mukorossi Gaertn. (S. mukorossi) on Cutibacterium acnes (C. acnes). The extract solvent and procedure were screened, based on the yield of saponins and minimum inhibitory concentration (MIC). The results showed that the optimized product, fermentation and ethyl acetate extract by adding isoamyl alcohol from water extract of S. mukorossi (SWFEAI), had the highest yield of saponins (7.83 +/- 0.26%) and the best antibacterial activity (MIC = 0.125 mg/mL) on C. acnes. The destroyed bacterial cell membrane and wall were observed by transmission electron microscopy, which then resulted in cell lysis and death. Furthermore, 20 compounds of SWFEAI were detected, among which oleanane-type triterpenoid saponins with molecular weights of 734, 750, 882, 924 and 966 were speculated to contribute to the antibacterial activities of SWFEAI. The results showed that SWFEAI could be a natural anti-acne agent.
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