Journal
NATURAL PRODUCT COMMUNICATIONS
Volume 14, Issue 12, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1934578X19896661
Keywords
Poly(3,5-dihydroxyhexanoic acid); antimycobacterial; biopolymer; endophyte; Annulohypoxylon multiforme; Juniperus communis; Scytosiphon lomentaria; medicinal plant; marine alga
Categories
Funding
- NSERC
- UNB
- NBIF
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The extracts of two isolates in our library of fungal endophytes, Annulohypoxylon multiforme (TC2-046) from the medicinal plant Juniperus communis and a sterile filamentous isolate (KP1-131DD) from the marine alga Scytosiphon lomentaria, displayed similar antimicrobial bioactivity profiles with notable high activity against Staphylococcus aureus. Bioassay-guided fractionation led to the isolation of poly(3R,5R-dihydroxyhexanoic acid) oligomers ranging from the trimer to the 29-mer that exhibited significant and selective inhibition of S. aureus and Mycobacterium tuberculosis H37Ra in vitro.
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