Journal
NANOSCALE RESEARCH LETTERS
Volume 15, Issue 1, Pages -Publisher
SPRINGEROPEN
DOI: 10.1186/s11671-020-3288-0
Keywords
Green fluorescent carbon dots; Bioimaging; DOX-CDs; Targeted delivery
Funding
- National Natural Science Foundation of China [81671744, 81771904, 81901798]
- China Postdoctoral Science Foundation [2016 M591923, 2017 T100405]
- Jiangsu Postdoctoral Science [1601189C]
- Natural Science Fund for Colleges and Universities in Jiangsu Province [19KJB310025]
- Startup Fund for Youth Talent in Xuzhou Medical University [D2019022]
- Science and Technology Development Program of Xuzhou [KC19141]
- project of Invigorating Health Care through Science, Technology and Education, Jiangsu Provincial Medical Youth Talent [QNRC2016782]
- Peak of Six Talents of Jiangsu Province [WSW-051]
- Jiangsu innovation and entrepreneurship training program for college students [201810313048Y]
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Doxorubicin entrapped carbon dots (DOX-CDs) were prepared for bioimaging and enhanced intracellular drug delivery. The CDs were synthesized via the hydrothermal method using citrate and urea under 200 degrees C for 1 h. Then, DOX was successfully conjugated on the CDs via physicochemical interactions. The DOX-CDs exhibited good crystal structure, remarkable aqueous stability, excellent photoluminescence property, and a high quantum yield of 93%. The fluorescent images revealed that the DOX-CDs could be readily taken up by the cancer cells for cell labeling. Furthermore, endo-lysosomal pH-assisted DOX release behavior was observed from DOX-CDs, and the cytotoxicity of DOX-CDs was confirmed by the MTS assay against H0-8910 ovarian cancer cells. In addition, the CDs indicated bright fluorescent signal in the animal imaging test and demonstrated low toxicity after administration for 7 and 21 days. Therefore, the prepared CDs could be a promising imaging probe for biomedical imaging and intracellular drug delivery.
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